The first enantiospecific synthesis of (−)-koumidine via the intramolecular palladium-catalyzed enolate driven cross coupling reaction. The stereospecific introduction of the 19-(Z) ethylidene side chain

Author:

Cao Hui,Yu Jianming,Wearing Xiangyu Z.,Zhang Chunchun,Liu Xiaoxiang,Deschamps Jeffery,Cook James M.

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Reference34 articles.

1. Bi, Y.; Hamaker, L. K.; Cook, J. M. In Studies in Natural Products Chemistry: Bioactive Natural Products; Basha, F. Z.; Rahman, A., Eds.; The Synthesis of Macroline Related Alkaloids; Elsevier Science: Amsterdam, 1993; Vol. 13, p. 383

2. Hamaker, L. K.; Cook, J. M. In Alkaloids: Chemical and Biological Perspectives; Pelletier, S. W., Ed.; The Synthesis of Macroline Related Sarpagine Alkaloids; Elsevier Science: New York, 1995; Vol. 9, p. 23

3. Lounasmaa, M.; Hanhinen, P.; Westersund, M. In The Alkaloids; Cordell, G. A., Ed.; The Sarpagine Group of Indole Alkaloids; Academic Press: San Diego, 1999

4. Revision of the stereochemistry of koumidine

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