Author:
Clive Derrick L.J.,Wang Jian
Subject
Organic Chemistry,Drug Discovery,Biochemistry
Reference23 articles.
1. Chemistry of Sponges. 19. Novel Bioactive Metabolites from Hamigera tarangaensis
2. Details of the biological tests have not been published; the antiviral activity is described as follows: Hamigeran B...showed 100% virus inhibition against both the Herpes and Polio viruses, with only slight cytotoxicity throughout the whole well at a concentration of 132 μg per disk.
3. Total Synthesis of Hamigerans: Part 1. Development of Synthetic Technology for the Construction of Benzannulated Polycyclic Systems by the Intramolecular Trapping of Photogenerated Hydroxy-o-quinodimethanes and Synthesis of Key Building Blocks This work was financially supported by the National Institutes of Health (USA) and The Skaggs Institute for Chemical Biology, and grants from Abbott, Amgen, ArrayBiopharma, Boehringer-Ingelheim, Glaxo, Hoffmann-La Roche, DuPont, Merck, Pfizer, and Schering Plough.
4. Total Synthesis of Hamigerans: Part 2. Implementation of the Intramolecular Diels–Alder Trapping of Photochemically Generated Hydroxy-o-quinodimethanes; Strategy and Completion of the Synthesis This work was financially supported by the National Institutes of Health (USA) and The Skaggs Institute for Chemical Biology, and grants from Abbott, Amgen, ArrayBiopharma, Boehringer-Ingelheim, Glaxo, Hoffmann-La Roche, DuPont, Merck, Pfizer, and Schering Plough.
5. The synthesis confirms the suggested absolute configuration; synthetic 1 had [α]D −168° (CHCl3) (personal communication from Professor K. C. Nicolaou).
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