Synthesis of a protected 2-aminocyclobutanone as a modular transition state synthon for medicinal chemistry
Author:
Funder
Major Research Instrumentation Program
Northwestern University
ECCS
Publisher
Elsevier BV
Subject
Organic Chemistry,Drug Discovery,Biochemistry
Reference19 articles.
1. Cyclobutanone und Cyclobutenone in der Natur und in der Synthese
2. The Application of Cyclobutane Derivatives in Organic Synthesis
3. Protease Inhibitors: Current Status and Future Prospects
4. Cyclobutanone Analogues of β-Lactams Revisited: Insights into Conformational Requirements for Inhibition of Serine- and Metallo-β-Lactamases
5. Cyclobutanone Mimics of Intermediates in Metallo-β-Lactamase Catalysis
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1. Cyclobutanone Inhibitors of Diaminopimelate Desuccinylase (DapE) as Potential New Antibiotics;International Journal of Molecular Sciences;2024-01-22
2. In Silico Binding of 2-Aminocyclobutanones to SARS-CoV-2 Nsp13 Helicase and Demonstration of Antiviral Activity;International Journal of Molecular Sciences;2023-03-07
3. Synthesis of α-Amino Cyclobutanones via Formal 1,3-Hydroxy Migration Triggered by Formation of α-Imino Rhodium Carbene;Organic Letters;2022-04-13
4. Heterogeneous Metal Catalysis for the Environmentally Benign Synthesis of Medicinally Important Scaffolds, Intermediates, and Building Blocks;Current Organic Chemistry;2021-11-01
5. Cyclobutanone Inhibitor of Cobalt-Functionalized Metallo-γ-Lactonase AiiA with Cyclobutanone Ring Opening in the Active Site;ACS Omega;2021-05-17
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