Copper(I)-catalyzed synthesis of isoindolo[1,2-b]quinazoline derivatives via an α-arylation under Pd and ligand free conditions

Author:

Zhang Yan,Liu Jian-Quan,Wang Xiang-Shan

Funder

NSFC of China

NSF of Jiangsu Province

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Reference60 articles.

1. Ji, M. Design and synthesis of novel 4-benzothiazole amino quinazolines Dasatinib derivatives as potential anti-tumor agents, Eur. J. Med. Chem. 2013, 63, 702-712. (b) Font, M.

2. Sanmartin, C. New insights into the structural requirements for pro-apoptotic agents based on 2,4-diaminoquinazoline, 2,4-diaminopyrido[2,3-d] pyrimidine and 2,4-diaminopyrimidine derivatives, Eur. J. Med. Chem. 2011, 46, 3887-3899. (c) Hour, M. J.

3. Lee, H. Z. Molecular modelling, synthesis, cytotoxicity and anti-tumour mechanisms of 2-aryl-6-substituted quinazolinones as dual-targeted anti-cancer agents, British J. Pharm. 2013, 169, 1574-1586. (d) Chen, Z.

4. Lou, Y. Anti-tumor effects of B-2, a novel 2,3-disubstituted 8-arylamino-3H-imidazo[4,5-g]quinazoline derivative, on the human lung adenocarcinoma A549 cell line in vitro and in vivo, Chem. Biol. Interact. 2011, 189, 90-99.

5. Cai, J.; Sun, M.; Wu, X.; Chen, J.; Wang, P.; Zong, X.; Ji, M. Design and synthesis of novel 4-benzothiazole amino quinazolines Dasatinib derivatives as potential anti-tumor agents, Eur. J. Med. Chem. 2013, 63, 702-712.

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