Acyltransferase domain swap in modular type I polyketide synthase to adjust the molecular gluing strength of rapamycin
Author:
Funder
Pfizer
National Institutes of Health
Publisher
Elsevier BV
Subject
Organic Chemistry,Drug Discovery,Biochemistry
Reference29 articles.
1. Assembly-Line Enzymology for Polyketide and Nonribosomal Peptide Antibiotics: Logic, Machinery, and Mechanisms
2. Engineered polyketides: Synergy between protein and host level engineering
3. Technical Advances to Accelerate Modular Type I Polyketide Synthase Engineering towards a Retro-biosynthetic Platform
4. Polyketide synthases as a platform for chemical product design
5. Comprehensive in Vitro Analysis of Acyltransferase Domain Exchanges in Modular Polyketide Synthases and Its Application for Short-Chain Ketone Production
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1. The malonyl/acetyl-transferase from murine fatty acid synthase is a promiscuous engineering tool for editing polyketide scaffolds;Communications Chemistry;2024-08-24
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3. The malonyl/acetyl-transferase from murine fatty acid synthase is a promiscuous engineering tool for editing polyketide scaffolds;2024-02-09
4. Current State‐of‐the‐Art Toward Chemoenzymatic Synthesis of Polyketide Natural Products;ChemBioChem;2023-09-15
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