Low temperature dehydrogenation of α-indoline nucleosides

Author:

Chandra Tilak,Zou Shawn,Brown Kenneth L.

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Reference10 articles.

1. Enzymatic Activity of Coenzyme B12 Derivatives with Altered Axial Nucleotides:  Probing the Mechanochemical Triggering Hypothesis in Ribonucleotide Reductase

2. Direct Evidence for the Conformational Deformation of the Corrin Ring by the Nucleotide Base in Vitamin B12: Synthesis and Solution Spectroscopic and Crystal Structure Analysis of Co.beta.-Cyanoimidazolylcobamide

3. Capture of a Labile Substrate by Expulsion of Water Molecules from the Active Site of Nicotinate Mononucleotide:5,6-Dimethylbenzimidazole Phosphoribosyltransferase (CobT) from Salmonella enterica

4. Brown, K. L.; Chandra, T.; Zou, S.; Valente, E. J. Chem. Commun., communicated. The indoline nucleosides were synthesized by coupling freshly prepared, silylated dimethylindoline/indoline base to an anomeric mixture of the protected sugar 2,3-O-(1-methylethylidene)5-O-(triphenylmethyl)α/β-d-ribofuranose by using 2-fluoro-1-methylpyridinium-p-toluenesulfonate as a condensing agent in 90–96% yield

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