An improved synthesis of the potent and selective γ-glutamyl transpeptidase inhibitor GGsTop together with an inhibitory activity evaluation of its potential hydrolysis products-Reference-Cited by-同舟云学术

An improved synthesis of the potent and selective γ-glutamyl transpeptidase inhibitor GGsTop together with an inhibitory activity evaluation of its potential hydrolysis products

Published:2017-09 Issue:38 Volume:58 Page:3700-3703
ISSN:0040-4039
Container-title:Tetrahedron Letters
language:en
Short-container-title:Tetrahedron Letters

Author:

Watanabe Bunta^ORCID,Morikita Tatsuya,Tabuchi Yukiko,Kobayashi Ryoto,Li Chunjie,Yamamoto Masakazu,Koeduka Takao,Hiratake Jun

Funder

Japan Science and Technology Agency

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Reference40 articles.

1. Design, Synthesis, and Evaluation of γ-Phosphono Diester Analogues of Glutamate as Highly Potent Inhibitors and Active Site Probes of γ-Glutamyl Transpeptidase

2. Phosphonate-based irreversible inhibitors of human γ-glutamyl transpeptidase (GGT). GGsTop is a non-toxic and highly selective inhibitor with critical electrostatic interaction with an active-site residue Lys562 for enhanced inhibitory activity

3. Gamma Glutamyl Transferase

4. Gamma‐Glutamyl Transpeptidase Substrate Specificity and Catalytic Mechanism

5. Gamma-glutamyl compounds: Substrate specificity of gamma-glutamyl transpeptidase enzymes

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