Vertical inhibition of PI3K/Akt/mTOR signaling demonstrates in vitro and in vivo anti-fibrotic activity-Reference-Cited by-同舟云学术

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Vertical inhibition of PI3K/Akt/mTOR signaling demonstrates in vitro and in vivo anti-fibrotic activity

Published:2014-11 Issue:2 Volume:76 Page:104-111
ISSN:0923-1811
Container-title:Journal of Dermatological Science
language:en
Short-container-title:Journal of Dermatological Science

Author:

Liang Minrui,Lv Jiaoyan,Chu Haiyan,Wang Jiucun,Chen Xiangjun,Zhu Xiaoxia,Xue Yu,Guan Ming,Zou Hejian

Funder

NIAID

Ministry of Science and Technology of China

Shanghai Medical College, Fudan University of China

Publisher

Elsevier BV

Subject

Dermatology,Molecular Biology,Biochemistry

Reference35 articles.

1. mTOR signaling in disease;Dazert;Curr Opin Cell Biol,2011

2. Treatment with rapamycin prevents fibrosis in tight-skin and bleomycin-induced mouse models of systemic sclerosis;Yoshizaki;Arthritis Rheum,2010

3. mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt;O’Reilly;Cancer Res,2006

4. PTEN loss in the continuum of common cancers, rare syndromes and mouse models;Hollander;Nat Rev Cancer,2011

5. AZD8055 is a potent, selective, and orally bioavailable ATP-competitive mammalian target of rapamycin kinase inhibitor with in vitro and in vivo antitumor activity;Chresta;Cancer Res,2010

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2. The multifaceted role of autophagy in skin autoimmune disorders: a guardian or culprit?;Frontiers in Immunology;2024-04-16

3. Mechanistic target of rapamycin (mTOR): a potential new therapeutic target for rheumatoid arthritis;Arthritis Research & Therapy;2023-10-02

4. The PI3K-Akt-mTOR and Associated Signaling Pathways as Molecular Drivers of Immune-Mediated Inflammatory Skin Diseases: Update on Therapeutic Strategy Using Natural and Synthetic Compounds;Cells;2023-06-20

5. Efficacy of topically applied rapamycin-loaded redox-sensitive nanocarriers in a human skin/T cell co-culture model;International Immunopharmacology;2023-04

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