Engineering T7 RNA polymerases for improved manufacturing of mRNA therapeutics-Reference-Cited by-同舟云学术

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Engineering T7 RNA polymerases for improved manufacturing of mRNA therapeutics

Published:2023-03 Issue:3 Volume:3 Page:100559
ISSN:2667-1093
Container-title:Chem Catalysis
language:en
Short-container-title:Chem Catalysis

Author:

Obexer Richard,Lovelock Sarah L.

Funder

Medical Research Council

University of Manchester

Faculty of Science and Engineering, University of Manchester

UK Research and Innovation

Publisher

Elsevier BV

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Chemistry (miscellaneous)

Reference10 articles.

1. Unlocking the promise of mRNA therapeutics;Rohner;Nat. Biotechnol.,2022

2. Incorporation of pseudouridine into mRNA yields superior nonimmunogenic vector with increased translational capacity and biological stability;Karikó;Mol. Ther.,2008

3. Generating the optimal mRNA for therapy: HPLC purification eliminates immune activation and improves translation of nucleoside-modified, protein-encoding mRNA;Karikó;Nucleic Acids Res.,2011

4. An engineered T7 RNA polymerase that produces mRNA free of immunostimulatory byproducts;Dousis;Nat. Biotechnol.,2022

5. Initiation, elongation, and processivity of carboxyl-terminal mutants of T7 RNA polymerase;Gardner;Biochemistry,1997

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