Optimization of the separation of (6R)- and (6S)- leucovorin and evaluation of the robustness of the optimum
Author:
Publisher
Elsevier BV
Subject
Organic Chemistry,General Medicine,Biochemistry,Analytical Chemistry
Reference9 articles.
1. Resolution of the stereoisomers of leucovorin and 5-methyltetrahydrofolate by chiral high-performance liquid chromatography
2. Direct resolution of the stereoisomers of leucovorin and 5-methyltetrahydrofolate using a bovine serum albumin high-performance liquid chromatographic chiral stationary phase coupled to an achiral phenyl column
3. Computer-aided optimisation of drug enantiomer separation in chiral high-performance liquid chromatography
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1. Experimental design-based optimization strategies for chromatographic and capillary electrophoretic separations;Handbook of Analytical Separations;2020
2. The Role of the Robustness/Ruggedness and Inertia Studies in Research and Development of Analytical Processes;Critical Reviews in Analytical Chemistry;2005-01
3. Evaluating the significance threshold in robustness testing. A critical discussion on the influence of time in molecular fluorescence spectrometry;Talanta;2002-01-04
4. High-performance liquid chromatographic method for determination of leucovorin in plasma: validation and application to a pharmacokinetic study in healthy volunteers;Biomedical Chromatography;2002
5. Optimization methods in chromatography and capillary electrophoresis;Journal of Chromatography A;2000-09
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