Dichloroacetate reactivates pyruvate-supported peroxide removal by liver mitochondria and prevents NAFLD aggravation in NAD(P)+ transhydrogenase-null mice consuming a high-fat diet-Reference-Cited by-同舟云学术

Dichloroacetate reactivates pyruvate-supported peroxide removal by liver mitochondria and prevents NAFLD aggravation in NAD(P)+ transhydrogenase-null mice consuming a high-fat diet

Published:2022-02 Issue: Volume:917 Page:174750
ISSN:0014-2999
Container-title:European Journal of Pharmacology
language:en
Short-container-title:European Journal of Pharmacology

Author:

Navarro Claudia D.C.,Francisco Annelise^ORCID,Figueira Tiago R.,Ronchi Juliana A.,Oliveira Helena C.F.^ORCID,Vercesi Anibal E.^ORCID,Castilho Roger F.

Funder

Conselho Nacional de Desenvolvimento Científico e Tecnológico

Fundação de Amparo à Pesquisa do Estado de São Paulo

Publisher

Elsevier BV

Subject

Pharmacology

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5. By inhibiting PDK, dichloroacetate prevents the phosphorylation of E1α and thus maintains PDC in active form;Babu;Oncogene,2011

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