A novel synthetic compound PHID (8-Phenyl-6a, 7, 8, 9, 9a, 10-hexahydro-6H-isoindolo [5, 6-g] quinoxaline-7, 9-dione) protects SH-SY5Y cells against MPP+-induced cytotoxicity through inhibition of reactive oxygen species generation and JNK signaling-Reference-Cited by-同舟云学术

A novel synthetic compound PHID (8-Phenyl-6a, 7, 8, 9, 9a, 10-hexahydro-6H-isoindolo [5, 6-g] quinoxaline-7, 9-dione) protects SH-SY5Y cells against MPP+-induced cytotoxicity through inhibition of reactive oxygen species generation and JNK signaling

Published:2011-01 Issue:1 Volume:650 Page:48-57
ISSN:0014-2999
Container-title:European Journal of Pharmacology
language:en
Short-container-title:European Journal of Pharmacology

Author:

Kim In Su,Koppula Sushruta,Kim Byung Wook,Song Min Dong,Jung Ju Yeon,Lee Gwang,Lee Hee Soon,Choi Dong-Kug

Publisher

Elsevier BV

Subject

Pharmacology

Reference64 articles.

1. MPP+ and MPP+ induced oxygen radical formation with mitochondrial enzymes;Adams;Free Radic. Biol. Med.,1993

2. Flow cytometric studies of oxidative product formation by neutrophils: a graded response to membrane stimulation;Bass;J. Immunol.,1983

3. Molecular pathways involved in the neurotoxicity of 6-OHDA, dopamine and MPTP: contribution to the apoptotic theory in Parkinson's disease;Blum;Prog. Neurobiol.,2001

4. Growth of a rat neuroblastoma cell line in serum-free supplemented medium;Bottenstein;Proc. Natl. Acad. Sci. U.S.A.,1979

5. The parkinsonian neurotoxin MPP+ opens the mitochondrial permeability transition pore and releases cytochrome c in isolated mitochondria via an oxidative mechanism;Cassarino;Biochim. Biophys. Acta,1999

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