Empagliflozin restores lowered exercise endurance capacity via the activation of skeletal muscle fatty acid oxidation in a murine model of heart failure

Author:

Nambu Hideo,Takada Shingo,Fukushima Arata,Matsumoto Junichi,Kakutani Naoya,Maekawa Satoshi,Shirakawa Ryosuke,Nakano Ippei,Furihata Takaaki,Katayama Takashi,Yamanashi Katsuma,Obata Yoshikuni,Saito Akimichi,Yokota Takashi,Kinugawa Shintaro

Funder

Scientific Research

Challenging Exploratory Research

Japan Foundation for Applied Enzymology

Hokkaido Heart Association

MSD Life Science Foundation

Uehara Memorial Foundation

Cardiovascular Research Fund, Tokyo, Japan

Fukuda Memorial Foundation for Medical Research

Kimura Memorial Heart Foundation Research

SENSHIN Medical Research Foundation

Nakatomi Foundation

Japan Heart Foundation

Japan Science Society

Japan Science and Technology Agency

Boehringer Ingelheim

Publisher

Elsevier BV

Subject

Pharmacology

Reference49 articles.

1. Pharmacologic and surgical interventions to improve functional capacity in heart failure;Abbate;Heart Fail. Clin.,2015

2. The failing heart relies on ketone bodies as a fuel;Aubert;Circulation,2016

3. Empagliflozin prevents worsening of cardiac function in an experimental model of pressure overload-induced heart failure;Byrne;JACC Basic Transl. Med.,2017

4. Anti-myostatin antibody increases muscle mass and strength and improves insulin sensitivity in old mice;Camporez;Proc. Natl. Acad. Sci. U.S.A.,2016

5. Effects of empagliflozin on cardiorespiratory fitness and significant interaction of loop diuretics;Carbone;Diabetes Obes. Metab.,2018

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