An aspartate in the second extracellular loop of the α1B adrenoceptor regulates agonist binding

Author:

Campbell Adrian P.,MacDougall Iain J.A.,Griffith Renate,Finch Angela M.

Funder

Australian Postgraduate Award

Publisher

Elsevier BV

Subject

Pharmacology

Reference27 articles.

1. Mutational analysis of the ɑ1A-adrenergic receptor binding pocket of antagonists by radioligand binding assay;Ahmed;Biol. Pharm. Bull.,2008

2. Catechol-binding serines of β2-adrenergic receptors control the equilibrium between active and inactive receptor states;Ambrosio;Mol. Pharmacol.,2000

3. Critical role for the second extracellular loop in the binding of both orthosteric and allosteric G protein-coupled receptor ligands;Avlani;J. Biol. Chem.,2007

4. Methods in Neurosciences;Ballesteros,1995

5. Operational models of pharmacological agonism;Black;Proc. R. Soc. Lond.,1983

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