TAS-203, an oral phosphodiesterase 4 inhibitor, exerts anti-inflammatory activities in a rat airway inflammation model

Author:

Demizu Shunsuke,Asaka Naomasa,Kawahara Hiroyuki,Sasaki Eiji

Publisher

Elsevier BV

Subject

Pharmacology

Reference32 articles.

1. Selective inhibition of phosphodiesterase type IV suppresses the chemotactic responsiveness of rat eosinophils in vitro;Alves;Eur. J. Pharmacol.,1996

2. Effects of the new benzimidazole derivative TAS-203, an orally active phosphodiesterase 4 inhibitor, on airway inflammation in rats and emetic responses in ferrets;Asaka;Arzneimittelforschung,2010

3. IL-13-induced changes in the goblet cell density of human bronchial epithelial cell cultures: map kinase and phosphatidylinositol 3-kinase regulation;Atherton;Am. J. Physiol. Lung Cell Mol. Physiol.,2003

4. Cyclic nucleotide phosphodiesterases: molecular regulation to clinical use;Bender;Pharmacol. Rev.,2006

5. Roflumilast in symptomatic chronic obstructive pulmonarydisease: two randomised clinical trials;Calverley;Lancet,2009

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