Neuroprotective effects of tetramethylpyrazine on spinal cord injury-Related neuroinflammation mediated by P2X7R/NLRP3 interaction

Author:

Fan Xiao,Zang Chunyan,Lao Kecheng,Mu Xiao-hong,Dai Shiyou

Funder

National Natural Science Foundation of China

Sichuan Provincial Administration of Traditional Chinese Medicine

Publisher

Elsevier BV

Subject

Pharmacology

Reference24 articles.

1. Spinal cord injury: pathophysiology, multimolecular interactions, and underlying recovery mechanisms;Anjum;Int. J. Mol. Sci.,2020

2. The role of microglia in modulating neuroinflammation after spinal cord injury;Brockie;Int. J. Mol. Sci.,2021

3. SIRT1 activation by 2,3,5,6-tetramethylpyrazine alleviates neuroinflammation via inhibiting M1 microglia polarization;Chen;Front. Immunol.,2023

4. P2X7 receptor (P2X7R) of microglia mediates neuroinflammation by regulating (NOD)-Like receptor protein 3 (NLRP3) inflammasome-dependent inflammation after spinal cord injury;Fan;Med. Sci. Mon. Int. Med. J. Exp. Clin. Res.,2020

5. The neuroanatomical-functional paradox in spinal cord injury;Fouad;Nat. Rev. Neurol.,2021

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