Interaction of the antiarrhythmic drug Amiodarone with the sodium channel Nav1.5 depends on the extracellular pH
Author:
Funder
Fundação de Amparo à Pesquisa do Estado de São Paulo
Conselho Nacional de Desenvolvimento Científico e Tecnológico
Publisher
Elsevier BV
Subject
Pharmacology
Reference35 articles.
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3. Physicochemical and analytical characteristics ofAmiodarone;Bonati;J. Pharmaceut. Sci.,1984
4. Effects of hyperkalemia, acidosis, and hypoxia on the depression of maximum rate of depolarization by class I antiarrhythmic drugs in Guinea pig myocardium: differential actions of class Ib and Ic agents;Campbell;J. Cardiovasc. Pharmacol.,1991
5. Protonation underlies tonic vs. use-dependent block;Carnevale;Proc. Natl. Acad. Sci. U.S.A.,2018
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