Berberine inhibits mouse insulin gene promoter through activation of AMP activated protein kinase and may exert beneficial effect on pancreatic β-cell

Author:

Shen Ning,Huan Yi,Shen Zhu-fang

Funder

National Nonprofit Institute Research Grant of CAMS-IMM

National Eleventh-Five Year Research Program of China

National S&T Major Special Project on Major New Drug Innovation

Publisher

Elsevier BV

Subject

Pharmacology

Reference23 articles.

1. Inhibition of lipid synthesis through activation of AMP kinase: an additional mechanism for the hypolipidemic effects of berberine;Brusq;J. Lipid Res.,2006

2. Berberine decreases PCSK9 expression in HepG2 cells;Cameron;Atherosclerosis,2008

3. Studies on the hypoglycemic effect of coptis chinensis and berberine;Chen;Acta Pharm. Sin.,1986

4. Endoplasmic reticulum stress and pancreatic b-cell death;Fonseca.;Trends Endocrinol. Metab.,2011

5. Translational regulation of proinsulin biosynthesis and proinsulin conversion in the pancreatic β-cell;Goodge;Semin. Cell Dev. Biol.,2000

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