Potency and efficacy of pharmacological PIP4K2 inhibitors in acute lymphoblastic leukemia

Author:

Lima Keli,Nogueira Frederico LisboaORCID,Cipelli MarcellaORCID,Carvalho Maria Fernanda Lopes,Pereira-Martins Diego Antonio,da Silva Wellington FernandesORCID,Cavaglieri Rita de Cássia,Nardinelli Luciana,Leal Aline de Medeiros,Velloso Elvira Deolinda Rodrigues Pereira,Bendit IsraelORCID,Câmara Niels Olsen Saraiva,Schuringa Jan Jacob,Machado-Neto João Agostinho,Rego Eduardo Magalhães

Funder

CAPES

FAPESP

Publisher

Elsevier BV

Reference23 articles.

1. Expanding role of PI5P4Ks in cancer: a promising druggable target;Arora;FEBS Lett.,2022

2. Pharmacological inhibition of PI5P4Kalpha/beta disrupts cell energy metabolism and selectively kills p53-null tumor cells;Chen;Proc. Natl. Acad. Sci. U. S. A.,2021

3. Next-generation sequencing in acute lymphoblastic Leukemia;Coccaro;Int. J. Mol. Sci.,2019

4. Depletion of a putatively druggable class of phosphatidylinositol kinases inhibits growth of p53-null tumors;Emerling;Cell,2013

5. PIP4K and the role of nuclear phosphoinositides in tumour suppression;Fiume;Biochim. Biophys. Acta,2015

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