Discovery of a novel small molecule PT109 with multi-targeted effects against Alzheimer's disease in vitro and in vivo-Reference-Cited by-同舟云学术

Discovery of a novel small molecule PT109 with multi-targeted effects against Alzheimer's disease in vitro and in vivo

Published:2020-09 Issue: Volume:883 Page:173361
ISSN:0014-2999
Container-title:European Journal of Pharmacology
language:en
Short-container-title:European Journal of Pharmacology

Author:

Chen Qiuhe,Tu Yalin,Mak Shinghung,Chen Jingkao,Lu Junfeng,Chen Chen,Yang Xiaohong,Wang Shengnan,Wen Shijun,Ma Shanshan,Li Mingtao,Han Yifan,Wah-Keung Tsim Karl,Pi Rongbiao

Funder

Guangdong Provincial International Cooperation Project of Science & Technology

National Natural Science Foundation of China

Guangzhou Science, Technology and Innovation Commission

Central Universities

Publisher

Elsevier BV

Subject

Pharmacology

Reference59 articles.

1. Rho GTPases as therapeutic targets in Alzheimer's disease;Aguilar;Alzheimer's Res. Ther.,2017

2. 2016 Alzheimer’s disease facts and figures;Alzheimer’s Association;Alzheimer’s Dementia,2016

3. 2019 Alzheimer’s disease facts and figures;Alzheimer’s Association;Alzheimer’s Dementia,2019

4. Role of inflammatory molecules in the Alzheimer's disease progression and diagnosis;Bagyinszky;J. Neurol. Sci.,2017

5. Rice bran derivatives alleviate microglia activation: possible involvement of MAPK pathway;Bhatia;J. Neuroinflammation,2016

Cited by 9 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. JNK3 inhibitors as promising pharmaceuticals with neuroprotective properties;Cell Adhesion & Migration;2024-02-15

2. Pharmacokinetic and safety profile of PT109B, a novel multi-targeted compound against Alzheimer's disease;European Journal of Pharmaceutical Sciences;2023-09

3. Does modulation of tau hyperphosphorylation represent a reasonable therapeutic strategy for Alzheimer’s disease? From preclinical studies to the clinical trials;Molecular Psychiatry;2023-06

4. Multi-Target-Directed Ligand Approach in Anti-Alzheimer’s Drug Discovery;Deciphering Drug Targets for Alzheimer’s Disease;2023

5. Recent advances of small molecule JNK3 inhibitors for Alzheimer’s disease;Bioorganic Chemistry;2022-11