Intracerebroventricular administration of CYX-6, a potent μ-opioid receptor agonist, a δ- and κ-opioid receptor antagonist and a biased ligand at μ, δ & κ-opioid receptors, evokes antinociception with minimal constipation and respiratory depression in rats in contrast to morphine-Reference-Cited by-同舟云学术

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Intracerebroventricular administration of CYX-6, a potent μ-opioid receptor agonist, a δ- and κ-opioid receptor antagonist and a biased ligand at μ, δ & κ-opioid receptors, evokes antinociception with minimal constipation and respiratory depression in rats in contrast to morphine

Published:2020-03 Issue: Volume:871 Page:172918
ISSN:0014-2999
Container-title:European Journal of Pharmacology
language:en
Short-container-title:European Journal of Pharmacology

Author:

Imam Mohammad Zafar,Kuo Andy,Ghassabian Sussan,Cai Yunxin,Qin Yajuan,Li Tingyou,Smith Maree T.

Funder

Research Training Program (RTP) Scholarship

UQ Graduate School Scholarship

Large Australian Research Council

Boehringer Ingelheim Pharma GmbH & Co. KG

Queensland Government Smart State Research Facilities Programme

Therapeutic Innovation Australia

National Collaborative Research Infrastructure Strategy

National Natural Science Foundation of China

Publisher

Elsevier BV

Subject

Pharmacology

Reference59 articles.

1. Effects of acute and repeated treatment with the biased mu opioid receptor agonist TRV130 (oliceridine) on measures of antinociception, gastrointestinal function, and abuse liability in rodents;Altarifi;J. Psychopharmacol.,2017

2. Opioid peptides: synthesis and biological activity of new endomorphin analogues;Biondi;Int. J. Pept. Res. Ther.,2006

3. Enhanced morphine analgesia in mice lacking beta-arrestin 2;Bohn;Science,1999

4. A potential novel strategy to separate therapeutic- and side-effects that are mediated via the same receptor: beta-arresting2/G-protein coupling antagonists;Bruns;J. Clin. Pharm. Ther.,2006

5. Behavioral and neuroendocrine actions of endomorphin-2;Bujdoso;Peptides,2001

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1. Peptide-derived ligands for the discovery of safer opioid analgesics;Drug Discovery Today;2024-05

2. Molecular Basis for Morphine Addiction;Malaysian Journal of Medicine and Health Sciences;2023-11-20

3. In Vitro Assessment of the Metabolic Stability of Two Novel Endomorphin-2 Analogs, CYX-5 and CYX-6, in Rat Liver Microsomes;European Journal of Drug Metabolism and Pharmacokinetics;2023-05-12

4. CYX-5, a G-protein biassed MOP receptor agonist, DOP receptor antagonist and KOP receptor agonist, evokes constipation but not respiratory depression relative to morphine in rats;Pharmacological Reports;2023-01-13

5. Analgesic Opioid Ligand Discovery Based on Nonmorphinan Scaffolds Derived from Natural Sources;Journal of Medicinal Chemistry;2022-01-07

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