Urotensin II prevents cardiomyocyte apoptosis induced by doxorubicin via Akt and ERK

Author:

Chen Yen-Ling,Loh Shih-Hurng,Chen Jin-Jer,Tsai Chien-Sung

Funder

National Science Council

Publisher

Elsevier BV

Subject

Pharmacology

Reference36 articles.

1. Human urotensin-II is a potent vasoconstrictor and agonist for the orphan receptor GPR14;Ames;Nature,1999

2. Urotensin-II blockade with SB-611812 attenuates cardiac dysfunction in a rat model of coronary artery ligation;Bousette;J. Mol. Cell. Cardiol.,2006

3. l-Carnitine reduces doxorubicin-induced apoptosis through a prostacyclin-mediated pathway in neonatal rat cardiomyocytes;Chao;Int. J. Cardiol.,2009

4. Reactive oxygen species modulate endothelin-I-induced c-fos gene expression in cardiomyocytes;Cheng;Cardiovasc. Res.,1999

5. Doxorubicin treatment in vivo causes cytochrome C release and cardiomyocyte apoptosis, as well as increased mitochondrial efficiency, superoxide dismutase activity, and Bcl-2:Bax ratio;Childs;Cancer Res.,2002

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