Complementary approaches involving monozygotic twins and single neuron genomics support postzygotic somatic mutations in schizophrenia
Author:
Funder
Natural Sciences and Engineering Research Council of Canada
Western University
Publisher
Elsevier BV
Subject
Biological Psychiatry,Psychiatry and Mental health
Reference17 articles.
1. Genetic mosaicism in the human brain: from lineage tracing to neuropsychiatric disorders;Bizzotto;Nat. Rev. Neurosci.,2022
2. Landmarks of human embryonic development inscribed in somatic mutations;Bizzotto;Science,2021
3. DNA methylation differences in monozygotic twin pairs discordant for schizophrenia identifies psychosis related genes and networks;Castellani;BMC Med. Genet.,2015
4. Post-zygotic genomic changes in glutamate and dopamine pathway genes may explain discordance of monozygotic twins for schizophrenia;Castellani;Clin. Transl. Med.,2017
5. Somatic variants in epilepsy - advancing gene discovery and disease mechanisms;Heinzen;Curr. Opin. Genet. Dev.,2020
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