Long-Range Interactions in the Alpha Subunit of Tryptophan Synthase Help to Coordinate Ligand Binding, Catalysis, and Substrate Channeling
Author:
Funder
National Science Foundation
Publisher
Elsevier BV
Subject
Molecular Biology,Structural Biology
Reference82 articles.
1. Allosteric regulation of substrate channeling and catalysis in the tryptophan synthase bienzyme complex;Dunn;Arch. Biochem. Biophys.,2012
2. Three-dimensional structure of the tryptophan synthase alpha 2 beta 2 multienzyme complex from Salmonella typhimurium;Hyde;J. Biol. Chem.,1988
3. Structural and kinetic analysis of a channel-impaired mutant of tryptophan synthase;Schlichting;J. Biol. Chem.,1994
4. The tryptophan synthase bienzyme complex transfers indole between the alpha- and beta-sites via a 25–30Å long tunnel;Dunn;Biochemistry,1990
5. Allosteric effects acting over a distance of 20–25Å in the Escherichia coli tryptophan synthase bienzyme complex increase ligand affinity and cause redistribution of covalent intermediates;Houben;Biochemistry,1990
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