Mechanism and Functional Significance of Itk Autophosphorylation
Author:
Publisher
Elsevier BV
Subject
Molecular Biology,Structural Biology
Reference40 articles.
1. Itk/Emt/Tsk activation in response to CD3 cross-linking in Jurkat T cells requires ZAP-70 and Lat and is independent of membrane recruitment;Shan;J. Biol. Chem.,1999
2. LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation;Zhang;Cell,1998
3. Lck phosphorylates the activation loop tyrosine of the Itk kinase domain and activates Itk kinase activity;Heyeck;J. Biol. Chem.,1997
4. Itk phosphorylation sites are required for functional activity in primary T cells;Wilcox;J. Biol. Chem.,2003
5. T cell receptor-initiated calcium release is uncoupled from capacitative calcium entry in Itk-deficient T cells;Liu;J. Expt. Med.,1998
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