Methylation of Cytosine at C5 in a CpG Sequence Context Causes a Conformational Switch of a Benzo[a]pyrene diol epoxide-N2-guanine Adduct in DNA from a Minor Groove Alignment to Intercalation with Base Displacement

Author:

Zhang Na,Lin Chin,Huang Xuanwei,Kolbanovskiy Aleksandr,Hingerty Brian E.,Amin Shantu,Broyde Suse,Geacintov Nicholas E.,Patel Dinshaw J.

Publisher

Elsevier BV

Subject

Molecular Biology,Structural Biology

Reference68 articles.

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2. Benzo[a]pyrene diol epoxides as intermediates in nucleic acid binding in vitro and in vivo;Weinstein;Science,1976

3. Binding of benzo[a]pyrene 7,8-diol-9,10-epoxides to DNA, RNA, and protein of mouse skin occurs with high stereoselectivity;Koreeda;Science,1978

4. Covalent bonding of bay-region diol epoxides to nucleic acids;Jerina;Advan. Expt. Med. Biol.,1991

5. Benzo[a]pyrene diol epoxide forms covalent adducts with deoxycytidylic acid by alkylation at both exocyclic amino N(4) and ring imino N-3 positions;Wolfe;Chem. Res. Toxicol.,2004

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