Structural Characterisation Reveals Mechanism of IL-13-Neutralising Monoclonal Antibody Tralokinumab as Inhibition of Binding to IL-13Rα1 and IL-13Rα2-Reference-Cited by-同舟云学术

Structural Characterisation Reveals Mechanism of IL-13-Neutralising Monoclonal Antibody Tralokinumab as Inhibition of Binding to IL-13Rα1 and IL-13Rα2

Published:2017-01 Issue:2 Volume:429 Page:208-219
ISSN:0022-2836
Container-title:Journal of Molecular Biology
language:en
Short-container-title:Journal of Molecular Biology

Author:

Popovic B.,Breed J.,Rees D.G.,Gardener M.J.,Vinall L.M.K.,Kemp B.,Spooner J.,Keen J.,Minter R.,Uddin F.,Colice G.,Wilkinson T.,Vaughan T.,May R.D.

Funder

AstraZeneca

Publisher

Elsevier BV

Subject

Molecular Biology,Structural Biology

Reference35 articles.

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3. Endogenously expressed IL-13Ralpha2 attenuates IL-13-mediated responses but does not activate signaling in human lung fibroblasts;Chandriani;J. Immunol.,2014

4. IL-13 receptor alpha2 selectively inhibits IL-13-induced responses in the murine lung;Zheng;J. Immunol.,2008

5. IL-13 antibodies influence IL-13 clearance in humans by modulating scavenger activity of IL-13Ralpha2;Kasaian;J. Immunol.,2011

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