Brazilin Removes Toxic Alpha-Synuclein and Seeding Competent Assemblies from Parkinson Brain by Altering Conformational Equilibrium-Reference-Cited by-同舟云学术

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Brazilin Removes Toxic Alpha-Synuclein and Seeding Competent Assemblies from Parkinson Brain by Altering Conformational Equilibrium

Published:2021-04 Issue:8 Volume:433 Page:166878
ISSN:0022-2836
Container-title:Journal of Molecular Biology
language:en
Short-container-title:Journal of Molecular Biology

Author:

Nahass George R.^ORCID,Sun Yuanzi,Xu Yong,Batchelor Mark^ORCID,Reilly Madeleine^ORCID,Benilova Iryna^ORCID,Kedia Niraja,Spehar Kevin^ORCID,Sobott Frank,Sessions Richard B.^ORCID,Caughey Byron^ORCID,Radford Sheena E.,Jat Parmjit S.,Collinge John,Bieschke Jan^ORCID

Funder

National Institutes of Health

Wellcome Trust

National Institute of Neurological Disorders and Stroke

Medical Research Council

National Institute of Allergy and Infectious Diseases

Publisher

Elsevier BV

Subject

Molecular Biology,Structural Biology

Reference70 articles.

1. Dependence of α-synuclein aggregate morphology on solution conditions;Hoyer;J. Mol. Biol.,2002

2. Direct visualization of alpha-synuclein oligomers reveals previously undetected pathology in Parkinson’s disease brain;Roberts;Brain,2015

3. Induction of α-synuclein aggregate formation by CSF exosomes from patients with Parkinson’s disease and dementia with Lewy bodies;Stuendl;Brain,2016

4. Stabilization of α-synuclein fibril clusters prevents fragmentation and reduces seeding activity and toxicity;Lam;Biochemistry,2016

5. α-Synuclein promotes SNARE-complex assembly in vivo and in vitro;Burré;Science (80-.),2010

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2. Modulation of cytotoxic amyloid fibrillation and mitochondrial damage of α-synuclein by catechols mediated conformational changes;Scientific Reports;2023-03-31

3. Controlling amyloid formation of intrinsically disordered proteins and peptides: slowing down or speeding up?;Essays in Biochemistry;2022-12

4. Myricetin Inhibits α‐Synuclein Amyloid Aggregation by Delaying the Liquid‐to‐Solid Phase Transition;ChemBioChem;2022-06-21

5. VCP suppresses proteopathic seeding in neurons;Molecular Neurodegeneration;2022-04-12

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