Enhancement of metabolic flux toward ε-poly-l-lysine biosynthesis by targeted inactivation of concomitant polyene macrolide biosynthesis in Streptomyces albulus

Author:

Yamanaka Kazuya,Hamano Yoshimitsu,Oikawa Tadao

Funder

JNC Corp.

Japan Society for the Promotion of Science (JSPS) grants-in-aid for scientific research

JSPS A3 Foresight Program

Publisher

Elsevier BV

Subject

Applied Microbiology and Biotechnology,Bioengineering,Biotechnology

Reference22 articles.

1. Polylysine produced by Streptomyces;Shima;Agric. Biol. Chem.,1977

2. Antimicrobial action of epsilon-poly-l-lysine;Shima;J. Antibiot. (Tokyo),1984

3. Biotechnological production of poly-epsilon-l-lysine for food and medical applications;Yamanaka,2010

4. Use of ADME studies to confirm the safety of epsilon-polylysine as a preservative in food;Hiraki;Regul. Toxicol. Pharmacol.,2003

5. Improved ε-poly-l-lysine production of an S-(2-aminoethyl)-l-cysteine resistant mutant of Streptomyces albulus;Hiraki;Seibutsu-kogaku Kaishi,1998

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