Farnesoid X receptor activation by the novel agonist TC-100 (3α, 7α, 11β-Trihydroxy-6α-ethyl-5β-cholan-24-oic Acid) preserves the intestinal barrier integrity and promotes intestinal microbial reshaping in a mouse model of obstructed bile acid flow-Reference-Cited by-同舟云学术

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Farnesoid X receptor activation by the novel agonist TC-100 (3α, 7α, 11β-Trihydroxy-6α-ethyl-5β-cholan-24-oic Acid) preserves the intestinal barrier integrity and promotes intestinal microbial reshaping in a mouse model of obstructed bile acid flow

Published:2022-09 Issue: Volume:153 Page:113380
ISSN:0753-3322
Container-title:Biomedicine & Pharmacotherapy
language:en
Short-container-title:Biomedicine & Pharmacotherapy

Author:

Marzano M.,Fosso Bruno,Colliva C.,Notario E.,Passeri D.,Intranuovo M.,Gioiello A.,Adorini L.,Pesole G.,Pellicciari R.,Moschetta A.,Gadaleta R.M.

Funder

Horizon 2020

Ministero dell’Istruzione, dell’Università e della Ricerca

Associazione Italiana per la Ricerca sul Cancro

Publisher

Elsevier BV

Subject

Pharmacology,General Medicine

Reference83 articles.

1. Food components and dietary habits: keys for a healthy gut microbiota composition;Rinninella;Nutrients,2019

2. Human microbiome in health and disease;Pflughoeft;Annu. Rev. Pathol.,2012

3. Role of the gut-liver axis in liver inflammation, fibrosis, and cancer: a special focus on the gut microbiota relationship;Ohtani;Hepatol. Commun.,2019

4. Microbial influences on epithelial integrity and immune function as a basis for inflammatory diseases;Macia;Immunol. Rev.,2012

5. Crosstalk between gut microbiota and innate immunity and its implication in autoimmune diseases;Jiao;Front. Immunol.,2020

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1. Molecular mechanism and therapeutic strategy of bile acids in Alzheimer’s disease from the emerging perspective of the microbiota–gut–brain axis;Biomedicine & Pharmacotherapy;2024-09

2. Increased hepatoprotective effects of the novel farnesoid X receptor agonist INT-787 versus obeticholic acid in a mouse model of nonalcoholic steatohepatitis;PLOS ONE;2024-04-25

3. Patented Farnesoid X receptor modulators: a review (2019 – present);Expert Opinion on Therapeutic Patents;2024-02-26

4. FXR agonists in NASH treatment;Journal of Hepatology;2023-11

5. Gut microbiota in the pathogenesis and therapeutic approaches of diabetes;eBioMedicine;2023-11

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