Characterization of a novel natural tetracenomycin reveals crucial role of 4-hydroxy group in ribosome binding

Author:

Alferova Vera A.,Maviza Tinashe P.,Biryukov Mikhail V.,Zakalyukina Yuliya V.,Polshakov Vladimir I.,Sergiev Petr V.,Korshun Vladimir A.,Osterman Ilya A.ORCID

Funder

Ministry of Education and Science of the Russian Federation

Publisher

Elsevier BV

Subject

General Medicine,Biochemistry

Reference13 articles.

1. Bacterial type II polyketide synthases;Hu,2020

2. Disclosing biosynthetic connections and functions of atypical angucyclinones with a fragmented C-ring;Mikhaylov;Nat. Prod. Rep.,2021

3. Investigation of the molecular landscape of bacterial aromatic polyketides by global analysis of type II polyketide synthases;Chen;Angew. Chem. Int. Ed.,2022

4. Tetracenomycin X inhibits translation by binding within the ribosomal exit tunnel;Osterman;Nat. Chem. Biol.,2020

5. Ribosome-targeting antibiotics and mechanisms of bacterial resistance;Wilson;Nat. Rev. Microbiol.,2014

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