Two-step polymer- and liposome-enzyme prodrug therapies for cancer: PDEPT and PELT concepts and future perspectives

Author:

Scomparin Anna,Florindo Helena F.,Tiram Galia,Ferguson Elaine L.,Satchi-Fainaro Ronit

Funder

European Union Seventh Framework Programme

Israel Science Foundation

Israeli Ministry of Health

Fundação para a Ciência e a Tecnologia

Publisher

Elsevier BV

Subject

Pharmaceutical Science

Reference183 articles.

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2. Retroviral-mediated gene therapy for the treatment of hepatocellular carcinoma: an innovative approach for cancer therapy;Huber;Proc. Natl. Acad. Sci. U. S. A.,1991

3. PDEPT: polymer-directed enzyme prodrug therapy;Satchi;Br. J. Cancer,2001

4. Polymer–drug conjugates, PDEPT and PELT: basic principles for design and transfer from the laboratory to clinic;Duncan;J. Control. Release,2001

5. Phase I clinical and pharmacokinetic study of PK1 [N-(2-hydroxypropyl)methacrylamide copolymer doxorubicin]: first member of a new class of chemotherapeutic agents—drug-polymer conjugates;Vasey;Clin. Cancer Res.,1999

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