The tumor EPR effect for cancer drug delivery: Current status, limitations, and alternatives

Author:

Sun Rui,Xiang Jiajia,Zhou Quan,Piao Ying,Tang Jianbin,Shao Shiqun,Zhou Zhuxian,Bae You Han,Shen Youqing

Funder

National Natural Science Foundation of China

Publisher

Elsevier BV

Subject

Pharmaceutical Science

Reference132 articles.

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2. Tumor vascular permeability and the EPR effect in macromolecular therapeutics: A review;Maeda;J. Control. Release,2000

3. Microvascular permeability of normal and neoplastic tissues;Gerlowski;Microvasc. Res.,1986

4. General mechanism of intratumor accumulation of macromolecules: advantage of macromolecular therapeutics;Matsumura;Cancer Chemother.,1987

5. Toward a full understanding of the EPR effect in primary and metastatic tumors as well as issues related to its heterogeneity;Maeda;Adv. Drug Delivery Rev.,2015

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