The efficacy of an anti-CD4 monoclonal antibody for HIV-1 treatment

Author:

Fessel W. Jeffrey,Anderson Brooke,Follansbee Stephen E.,Winters Mark A.,Lewis Stanley T.,Weinheimer Steven P.,Petropoulos Christos J.,Shafer Robert W.

Publisher

Elsevier BV

Subject

Virology,Pharmacology

Reference13 articles.

1. Development of anti-CD4 MAb hu5A8 for treatment of HIV-1 infection: preclinical assessment in non-human primates;Boon;Toxicology,2002

2. Inhibition of HIV infection by a novel CD4 domain 2-specific monoclonal antibody. Dissecting the basis for its inhibitory effect on HIV-induced cell fusion;Burkly;J. Immunol.,1992

3. Crystal structure of HIV-1 primary receptor CD4 in complex with a potent antiviral antibody;Freeman;Structure,2010

4. Antibodies for HIV treatment and prevention: window of opportunity?;Huber;Curr. Top. Microbiol. Immunol.,2008

5. Safety, pharmacokinetics, and antiretroviral activity of multiple doses of ibalizumab (formerly TNX-355), an anti-CD4 monoclonal antibody, in human immunodeficiency virus type 1-infected adults;Jacobson;Antimicrob. Agents Chemother.,2009

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