Molecular mechanism of rhinovirus escape from the Pyrazolo[3,4-d]pyrimidine capsid-binding inhibitor OBR-5-340 via mutations distant from the binding pocket: Derivatives that brake resistance-Reference-Cited by-同舟云学术

Molecular mechanism of rhinovirus escape from the Pyrazolo[3,4-d]pyrimidine capsid-binding inhibitor OBR-5-340 via mutations distant from the binding pocket: Derivatives that brake resistance

Published:2024-02 Issue: Volume:222 Page:105810
ISSN:0166-3542
Container-title:Antiviral Research
language:en
Short-container-title:Antiviral Research

Author:

Richter Martina,Döring Kristin,Blaas Dieter^ORCID,Riabova Olga,Khrenova Maria,Kazakova Elena^ORCID,Egorova Anna^ORCID,Makarov Vadim^ORCID,Schmidtke Michaela^ORCID

Publisher

Elsevier BV

Reference49 articles.

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3. Optimization of the additive CHARMM all-atom protein force field targeting improved sampling of the backbone phi, psi and side-chain chi(1) and chi(2) dihedral angles;Best;J. Chem. Theor. Comput.,2012

4. Molecular mechanism of a specific capsid binder resistance caused by mutations outside the binding pocket;Braun;Antivir. Res.,2015

5. Respiratory infections in children and adolescents in Germany during the COVID-19 pandemic;Buchholz;J. Health Monit.,2023

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1. Dynamic features of virus protein 1 and substitutions in the 3-phenyl ring determine the potency and broad-spectrum activity of capsid-binding pyrazolo[3,4-d]pyrimidines against rhinoviruses;Antiviral Research;2024-11