The anti-inflammatory drug celecoxib inhibits t-type Ca2+ currents in spermatogenic cells yet it elicits the acrosome reaction in mature sperm

Author:

Balderas E.,Sánchez-Cárdenas C.,Chávez J.C.,de la Vega Beltrán J.L.,Gómez-Lagunas F.,Treviño C.L.,Darszon A.

Funder

Consejo Nacional de Ciencia y Tecnología (CONACyT)

National Institutes of Health (NIH)

Dirección General de Asuntos del Personal Académico/Universidad Nacional Autónoma de México

Publisher

Wiley

Subject

Cell Biology,Genetics,Molecular Biology,Biochemistry,Structural Biology,Biophysics

Reference43 articles.

1. Induction of a fast inactivation gating on delayed rectifier Shab K(+) channels by the anti-inflammatory drug Celecoxib;Arias-Olguín;Channels,2011

2. Activation of mouse sperm T-type Ca2+ channels by adhesion to the egg zona pellucid;Arnoult;Proc. Natl. Acad. Sci. USA,1996

3. Pharmacological properties of the T-type Ca2+ current of mouse spermatogenic cells;Arnoult;Mol. Pharmacol.,1998

4. Niflumic acid blocks native and recombinant T-type channels;Balderas;J. Cell. Physiol.,2012

5. The CatSper channel: a polymodal chemosensor in human sperm;Brenker;EMBO J.,2012

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