The N137 and P140 amino acids in the p51 and the P95 amino acid in the p66 subunit of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase are instrumental to maintain catalytic activity and to design new classes of anti-HIV-1 drugs-Reference-Cited by-同舟云学术

The N137 and P140 amino acids in the p51 and the P95 amino acid in the p66 subunit of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase are instrumental to maintain catalytic activity and to design new classes of anti-HIV-1 drugs

Published:2005-03-24 Issue:11 Volume:579 Page:2294-2300
ISSN:0014-5793
Container-title:FEBS Letters
language:en
Short-container-title:

Author:

Auwerx Joeri,Van Nieuwenhove Joke,Rodríguez-Barrios Fátima,de Castro Sonia,Velázquez Sonsoles,Ceccherini-Silberstein Francesca,De Clercq Erik,Camarasa María-José,Perno Carlo-Federico,Gago Federico,Balzarini Jan

Publisher

Wiley

Subject

Cell Biology,Genetics,Molecular Biology,Biochemistry,Structural Biology,Biophysics

Reference27 articles.

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4. Suppression of resistance to drugs targeted to human immunodeficiency virus reverse transcriptase by combination therapy;Balzarini;Biochem. Pharmacol.,1999

5. Mutational analysis of trp-229 of human immunodeficiency virus type 1 reverse transcriptase (RT) identifies this amino acid residue as a prime target for the rational design of new non-nucleoside RT inhibitors;Pelemans;Mol. Pharmacol.,2000

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3. An Alternative HIV-1 Non-Nucleoside Reverse Transcriptase Inhibition Mechanism: Targeting the p51 Subunit;Molecules;2020-12-13

4. Peptides Mimicking the β7/β8 Loop of HIV-1 Reverse Transcriptase p51 as “Hotspot-Targeted” Dimerization Inhibitors;ACS Medicinal Chemistry Letters;2020-01-24

5. An alternative HIV-1 non-nucleoside Reverse Transcriptase inhibition mechanism: Targeting the p51 subunit;2019-07-13