Synthesis and influenza virus sialidase inhibitory activity of the 5-desacetamido analogue of 2,3-didehydro-2,4-dideoxy-4-guanidinyl-N-acetylneuraminic acid (GG167)

Author:

Starkey Ian D.,Mahmoudian Mahmoud,Noble David,Smith Paul W.,Cherry Peter C.,Howes Peter D.,Sollis Steven L.

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Reference16 articles.

1. Rational design of potent sialidase-based inhibitors of influenza virus replication

2. Molecular Modeling Studies on Ligand Binding to Sialidase from Influenza Virus and the Mechanism of Catalysis

3. Preparation of derivatives and analogues of 2-deoxy-2,3-dehydro-N-acetylneuraminic acid as antiviral agents. von Itzstein M, Wu W-Y, Van P. T, Danylec B and Jin B. World patent WO 9116320.

4. Preparation of neuraminic acid derivatives. Chandler M and Weir N.G, World patent WO 9312105.

5. The synthesis of 2,3-didehydro-2,4-dideoxy-4-guanidinyl-N-acetylneuraminic acid: a potent influenza virus sialidase inhibitor

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