Synthetic studies of 18-membered anti-tumor macrolide, tedanolide. Computer-aided conformational design of a seco-acid derivative for efficient macrolactonization-Reference-Cited by-同舟云学术

Synthetic studies of 18-membered anti-tumor macrolide, tedanolide. Computer-aided conformational design of a seco-acid derivative for efficient macrolactonization

Published:1996-01 Issue:3 Volume:37 Page:385-388
ISSN:0040-4039
Container-title:Tetrahedron Letters
language:en
Short-container-title:Tetrahedron Letters

Author:

Matsushima Tomohiro,Horita Kiyoshi,Nakajima Noriyuki,Yonemitsu Osamu

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Reference11 articles.

1. Tedanolide: a potent cytotoxic macrolide from the Caribbean sponge Tedania ignis

2. Chiral synthesis of polyketide-derived natural products. 27. Stereoselective synthesis of erythronolide A via an extremely efficient macrolactonization by the modified Yamaguchi method

3. Stereoselective synthesis of erythronolide a by extremely efficient lactonization based on conformational adjustment and high activation of seco-acid1

4. Chiral synthesis of polyketide-derived natural products. 28. Synthesis of 16-membered macrolide aglycons, carbonolide A, leuconolides, and maridonolides, via carbonolide B type compounds by virtue of completely stereoselective epoxidation and reduction based on the conformational control of macrolide rings with protecting groups

5. Chiral synthesis of polyketide-derived natural products. XXXIV. Facile total synthesis of carbonolides by Witting-Horner macro-cyclization and stereoselective expoxidation.

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