Inhibitors of sterol synthesis. An efficient and specific side chain oxidation of 3β-hydroxy-5α-cholest-8(14)-en-15-one. Facile access to its metabolites and analogs.-Reference-Cited by-同舟云学术

Inhibitors of sterol synthesis. An efficient and specific side chain oxidation of 3β-hydroxy-5α-cholest-8(14)-en-15-one. Facile access to its metabolites and analogs.

Published:1991-08 Issue:32 Volume:32 Page:3923-3926
ISSN:0040-4039
Container-title:Tetrahedron Letters
language:en
Short-container-title:Tetrahedron Letters

Author:

Herz Josef E.,Swaminathan Shankar,Wilson William K.,Schroepfer George J.

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Reference21 articles.

1. Inhibition of sterol biosynthesis in L cells and mouse liver cells by 15-oxygenated sterols.

2. Inhibitors of sterol synthesis. Studies of the metabolism of 5α-cholest-8(14)-en-3β-ol-15-one in Chinese hamster ovary cells and its effects on activities of early enzymes in cholesterol biosynthesis

3. 5α-Cholest-8(14)-EN-3β-OL-15-one. A competitive substrate for acyl coenzyme a:Cholesterol acyl transferase

4. Inhibitors of sterol synthesis. Effect of dietary 5α-cholest-8(14)-EN-3β-OL-15-one on acat activity of jejunal microsomes of the rat

5. Inhibitors of sterol synthesis. Dietary administration of 5α-cholest-8(14)-en-3β-ol-15-one inhibits the intestinal absorption of cholesterol in lymph-cannulated rats

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