Discovery of compounds that reactivate p53 mutants in vitro and in vivo-Reference-Cited by-同舟云学术

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Discovery of compounds that reactivate p53 mutants in vitro and in vivo

Published:2022-09 Issue:9 Volume:29 Page:1381-1395.e13
ISSN:2451-9456
Container-title:Cell Chemical Biology
language:en
Short-container-title:Cell Chemical Biology

Author:

Durairaj Geetha,Demir Özlem,Lim Bryant,Baronio Roberta,Tifrea Delia,Hall Linda V.,DeForest Jacob C.,Lauinger Linda,Jebril Fallatah Maryam M.,Yu Clinton,Bae Hosung,Lin Da-Wei,Kim Jin Kwang,Salehi Faezeh,Jang Cholsoon,Qiao Feng,Lathrop Richard H.,Huang Lan,Edwards Robert,Rychnovsky Scott,Amaro Rommie E.,Kaiser Peter

Funder

National Science Foundation

National Institutes of Health

DOD

University of California

Publisher

Elsevier BV

Subject

Clinical Biochemistry,Drug Discovery,Pharmacology,Molecular Biology,Molecular Medicine,Biochemistry

Reference49 articles.

1. Reactivation of mutant p53 by a dietary-related compound phenethyl isothiocyanate inhibits tumor growth;Aggarwal;Cell Death Differ.,2016

2. Gain-of-function mutant p53: history and speculation;Bargonetti;J. Mol. Cell Biol.,2019

3. All-codon scanning identifies p53 cancer rescue mutations;Baronio;Nucleic Acids Res.,2010

4. Restoration of p53 function: a new therapeutic strategy to induce tumor regression?;Beraza;Hepatology,2007

5. Reactivating mutant p53 using small molecules as zinc metallochaperones: awakening a sleeping giant in cancer;Blanden;Drug Discov. Today,2015

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2. Pyrimidine Triones as Potential Activators of p53 Mutants;Biomolecules;2024-08-08

3. An engineered DNA aptamer-based PROTAC for precise therapy of p53-R175H hotspot mutant-driven cancer;Science Bulletin;2024-07

4. Structural basis of p53 inactivation by cavity-creating cancer mutations and its implications for the development of mutant p53 reactivators;Cell Death & Disease;2024-06-11

5. Toward physics‐based precision medicine: Exploiting protein dynamics to design new therapeutics and interpret variants;Protein Science;2024-02-15

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