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A Systems Pharmacology Approach Uncovers Wogonoside as an Angiogenesis Inhibitor of Triple-Negative Breast Cancer by Targeting Hedgehog Signaling

  • Published:2019-08 Issue:8 Volume:26 Page:1143-1158.e6
  • ISSN:2451-9456
  • Container-title:Cell Chemical Biology
  • language:en
  • Short-container-title:Cell Chemical Biology

Author:

Huang Yujie,Fang Jiansong,Lu Weiqiang,Wang Zihao,Wang Qi,Hou Yuan,Jiang Xingwu,Reizes Ofer,Lathia Justin,Nussinov Ruth,Eng Charis,Cheng Feixiong

Funder

NIH

Frederick National Laboratory for Cancer Research

Center for Cancer Research

Publisher

Elsevier BV

Subject

Clinical Biochemistry,Drug Discovery,Pharmacology,Molecular Biology,Molecular Medicine,Biochemistry

Reference77 articles.

1. Molecular characterization of breast cancer with high-resolution oligonucleotide comparative genomic hybridization array;Andre;Clin. Cancer Res.,2009

2. Unravelling triple-negative breast cancer molecular heterogeneity using an integrative multiomic analysis;Bareche;Ann. Oncol.,2018

3. Pleiotropic effects of statins: new therapeutic targets in drug design;Bedi;Naunyn Schmiedeberg's Arch. Pharmacol.,2016

4. Controlling the false discovery rate: a practical and powerful approach to multiple testing;Benjamini;J. R. Stat. Soc.,1995

5. Triple-negative breast cancer: challenges and opportunities of a heterogeneous disease;Bianchini;Nat. Rev. Clin. Oncol.,2016
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