EED-Targeted PROTACs Degrade EED, EZH2, and SUZ12 in the PRC2 Complex-Reference-Cited by-同舟云学术

EED-Targeted PROTACs Degrade EED, EZH2, and SUZ12 in the PRC2 Complex

Published:2020-01 Issue:1 Volume:27 Page:41-46.e17
ISSN:2451-9456
Container-title:Cell Chemical Biology
language:en
Short-container-title:Cell Chemical Biology

Author:

Hsu Jessie Hao-Ru,Rasmusson Timothy,Robinson James,Pachl Fiona,Read Jon,Kawatkar Sameer,O’ Donovan Daniel H.,Bagal Sharan,Code Erin,Rawlins Philip,Argyrou Argyrides,Tomlinson Ronald,Gao Ning,Zhu Xiahui,Chiarparin Elisabetta,Jacques Kelly,Shen Minhui,Woods Haley,Bednarski Emma,Wilson David M.,Drew Lisa,Castaldi M. Paola,Fawell Stephen,Bloecher Andrew

Funder

AstraZeneca

Publisher

Elsevier BV

Subject

Clinical Biochemistry,Drug Discovery,Pharmacology,Molecular Biology,Molecular Medicine,Biochemistry

Reference20 articles.

1. Catalytic in vivo protein knockdown by small-molecule PROTACs;Bondeson;Nat. Chem. Biol.,2015

2. Targeting the von Hippel-Lindau E3 ubiquitin ligase using small molecules to disrupt the VHL/HIF-1α interaction;Buckley;J. Am. Chem. Soc.,2012

3. Epigenetics during EMT in lung cancer: EZH2 as a potential therapeutic target;Dimou;Cancer Treat. Res. Commun.,2017

4. Identification of EZH2 and EZH1 small molecule inhibitors with selective impact on diffuse large B cell lymphoma cell growth;Garapaty-Rao;Chem. Biol.,2013

5. The EED protein-protein interaction inhibitor A-395 inactivates the PRC2 complex;He;Nat. Chem. Biol.,2017

Cited by 151 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Amphiphilic Affibody-PROTAC conjugate Self-Assembled nanoagents for targeted cancer therapy;Chemical Engineering Journal;2024-09

2. Lineage-specific canonical and non-canonical activity of EZH2 in advanced prostate cancer subtypes;Nature Communications;2024-08-08

3. Chromatin remodellers as therapeutic targets;Nature Reviews Drug Discovery;2024-07-16

4. Application and challenges of nitrogen heterocycles in PROTAC linker;European Journal of Medicinal Chemistry;2024-07

5. Identification of Proteolysis Targeting Chimeras (PROTACs) for Lysine Demethylase 5 and Their Neurite Outgrowth-Promoting Activity;Chemical and Pharmaceutical Bulletin;2024-07-01