Validation and Invalidation of Chemical Probes for the Human N-myristoyltransferases

Author:

Kallemeijn Wouter W.ORCID,Lueg Gregor A.,Faronato Monica,Hadavizadeh Kate,Goya Grocin Andrea,Song Ok-Ryul,Howell Michael,Calado Dinis P.,Tate Edward W.

Funder

The Royal Society

European Commission

MRC

CDA

Cancer Research UK

Francis Crick Institute

UK Medical Research Council

Wellcome Trust

Publisher

Elsevier BV

Subject

Clinical Biochemistry,Drug Discovery,Pharmacology,Molecular Biology,Molecular Medicine,Biochemistry

Reference50 articles.

1. The promise and peril of chemical probes;Arrowsmith;Nat. Chem. Biol.,2015

2. Bell, A.S., Tate, E.W., Leatherbarrow, R.J., Hutton, J.A., and Brannigan, J.A. (2017). Compounds and their use as inhibitors of N-myristoyl transferase. Patent PCT In Appl (2017) WO 2017001812.

3. Tris (dibenzylideneacetone)dipalladium, a N-myristoyltransferase-1 inhibitor, is effective against melanoma growth in vitro and in vivo;Bhandarkar;Clin. Cancer Res.,2008

4. (1S,2R)-D-erythro-2-(N-myristoylamino)-1-phenyl-1-propanol as an inhibitor of ceramidase;Bielawska;J. Biol. Chem.,1996

5. Choose and use your chemical probe wisely to explore cancer biology;Blagg;Cancer Cell,2017

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