HDAC Inhibitor-Induced Mitotic Arrest Is Mediated by Eg5/KIF11 Acetylation

Author:

Nalawansha Dhanusha A.,Gomes Inosha D.,Wambua Magdalene K.,Pflum Mary Kay H.

Funder

NIH

Wayne State University

Publisher

Elsevier BV

Subject

Clinical Biochemistry,Drug Discovery,Pharmacology,Molecular Biology,Molecular Medicine,Biochemistry

Reference56 articles.

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2. Antiproliferative and proapoptotic effects of histone deacetylase inhibitors on gastrointestinal neuroendocrine tumor cells;Baradari;Endocr. Relat. Cancer,2006

3. Histone deacetylase inhibitors all induce p21 but differentially cause tubulin acetylation, mitotic arrest, and cytotoxicity;Blagosklonny;Mol. Cancer Ther.,2002

4. Phosphorylation by p34cdc2 regulates spindle association of human Eg5, a kinesin-related motor essential for bipolar spindle formation in vivo;Blangy;Cell,1995

5. Identification of p130cas as an in vivo substrate of receptor protein-tyrosine phosphatase alpha;Buist;J. Biol. Chem.,2000

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