The High Genetic Barrier of EFdA/MK-8591 Stems from Strong Interactions with the Active Site of Drug-Resistant HIV-1 Reverse Transcriptase-Reference-Cited by-同舟云学术

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The High Genetic Barrier of EFdA/MK-8591 Stems from Strong Interactions with the Active Site of Drug-Resistant HIV-1 Reverse Transcriptase

Published:2018-10 Issue:10 Volume:25 Page:1268-1278.e3
ISSN:2451-9456
Container-title:Cell Chemical Biology
language:en
Short-container-title:Cell Chemical Biology

Author:

Takamatsu Yuki,Das Debananda,Kohgo Satoru,Hayashi Hironori,Delino Nicole S.,Sarafianos Stefan G.,Mitsuya Hiroaki,Maeda Kenji

Funder

Intramural Research Program of Center for Cancer Research, National Cancer Institute

NIH

JSPS KAKENHI

AMED

National Center for Global Health and Medicine Research Institute

Publisher

Elsevier BV

Subject

Clinical Biochemistry,Drug Discovery,Pharmacology,Molecular Biology,Molecular Medicine,Biochemistry

Reference46 articles.

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2. Identification and characterization of mutations in hepatitis B virus resistant to lamivudine. Lamivudine Clinical Investigation Group;Allen;Hepatology,1998

3. Comparisons of the HBV and HIV polymerase, and antiviral resistance mutations;Bartholomeusz;Antivir. Ther.,2004

4. Analysis of mutations at positions 115 and 116 in the dNTP binding site of HIV-1 reverse transcriptase;Boyer;Proc. Natl. Acad. Sci. USA,2000

5. Why do HIV-1 and HIV-2 use different pathways to develop AZT resistance;Boyer;PLoS Pathog.,2006

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