Importance of a hypervariable active-site residue in human Mu class glutathione transferases catalyzing the bioactivation of chemotherapeutic thiopurine prodrugs-Reference-Cited by-同舟云学术

Importance of a hypervariable active-site residue in human Mu class glutathione transferases catalyzing the bioactivation of chemotherapeutic thiopurine prodrugs

Published:2007-08 Issue:8 Volume:1770 Page:1098-1103
ISSN:0304-4165
Container-title:Biochimica et Biophysica Acta (BBA) - General Subjects
language:en
Short-container-title:Biochimica et Biophysica Acta (BBA) - General Subjects

Author:

Eklund Birgitta I.,Mannervik Bengt

Publisher

Elsevier BV

Subject

Molecular Biology,Biochemistry,Biophysics

Reference26 articles.

1. Divergent activities of human glutathione transferases in the bioactivation of azathioprine;Eklund;Mol. Pharmacol.,2006

2. Human glutathione transferases catalyzing the bioactivation of anticancer thiopurine prodrugs;Eklund;Biochem. Pharmacol.,2007

3. Reviewing the mechanism of action of thiopurine drugs: towards a new paradigm in clinical practice;Cara;Med. Sci. Monit.,2004

4. Cytotoxicity of the novel glutathione-activated thiopurine prodrugs cis-AVTP [cis-6-(2-acetylvinylthio)purine] and trans-AVTG [trans-6-(2-acetylvinylthio)guanine] results from the National Cancer Institute's anticancer drug screen;Gunnarsdottir;Drug Metab. Dispos.,2004

5. Novel glutathione-dependent thiopurine prodrugs: evidence for enhanced cytotoxicity in tumor cells and for decreased bone marrow toxicity in mice;Gunnarsdottir;J. Pharmacol. Exp. Ther.,2002

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3. Deletion of Glutathione-S-Transferase M1 Reduces Azathioprine Metabolite Concentrations in Young Patients With Inflammatory Bowel Disease;Journal of Clinical Gastroenterology;2014-01

4. Oral Azathioprine Leads to Higher Incorporation of 6-Thioguanine in DNA of Skin than Liver: The Protective Role of the Keap1/Nrf2/ARE Pathway;Cancer Prevention Research;2011-07-29

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