Conformational dynamics of CYP3A4 demonstrate the important role of Arg212 coupled with the opening of ingress, egress and solvent channels to dehydrogenation of 4-hydroxy-tamoxifen

Author:

Shahrokh Kiumars,Cheatham Thomas E.,Yost Garold S.

Funder

NIH

NSF TeraGrid

Publisher

Elsevier BV

Subject

Molecular Biology,Biochemistry,Biophysics

Reference69 articles.

1. Cytochrome P450 enzymes in drug metabolism and chemical toxicology: an introduction;Furge;Biochem. Mol. Biol. Educ.,2006

2. Substrate Oxidation by Cytochrome P450 Enzymes Cytochrome P450;Ortiz de Montellano,2005

3. Conformational plasticity and structure/function relationships in cytochromes P450;Pochapsky;Antioxid. Redox Signal.,2010

4. Structure and function of cytochromes P450 2B: from mechanism-based inactivators to X-ray crystal structures and back;Halpert;Drug Metab. Dispos.,2011

5. What common structural features and variations of mammalian P450s are known to date?;Otyepka;Biochim. Biophys. Acta, Gen. Subj.,2007

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