Enriched chitosan nanoparticles loaded with siRNA are effective in lowering Huntington's disease gene expression following intranasal administration

Author:

Sava Vasyl,Fihurka Oksana,Khvorova Anastasia,Sanchez-Ramos Juan

Funder

National Institutes of Health

NIH

Publisher

Elsevier BV

Subject

Pharmaceutical Science,General Materials Science,Biomedical Engineering,Molecular Medicine,Medicine (miscellaneous),Bioengineering

Reference18 articles.

1. Huntington's disease: from molecular pathogenesis to clinical treatment;Ross;Lancet Neurol,2011

2. The Huntington's disease collaborative research group;A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes;Cell,1993

3. Animal models of Huntington's disease;Ramaswamy;ILAR J,2007

4. Landwehrmeyer GB;Tabrizi,2019

5. Mouse models of Huntington's disease and methodological considerations for therapeutic trials;Ferrante;Biochim Biophys Acta,2009

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