Safety Pharmacology II-CV, GI, Respiratory and Renal Safety

Author:

Williams Michael,Porsolt Roger D.,Lacroix Pierre

Publisher

Elsevier

Reference20 articles.

1. ICH S7A: Safety Pharmacology studies for human pharmaceuticals;Anon;The European Agency for the Evaluation of Medicinal Products. Evaluation of Medicines for Human Use. CPMP/ICH/539/00,2000

2. ICH S7B: The non-clinical evaluation of the potential for delayed ventricular repolarization (QT interval prolongation) by human pharmaceuticals. Step 2 Revision;Anon;US Food and Drug Administration, Department of Health and Human Services, Rockville, MD 20857-0001,2004

3. Clinical relevance of cardiac arrhythmias generated by afterdepolarizations. Role of M cells in the generation of U waves, triggered activity and torsade de pointes;Antzelevitch;J. Am. Coll. Cardiol.,1994

4. Measurement of bronchoconstriction using whole-body plethysmograph: comparison of freely moving versus restrained guinea pigs;Chong;J. Pharmacol. Tox. Meth.,1998

5. Loratadine blockade of K(+) channels in human heart: comparison with terfenadine under physiological conditions;Crumb;J. Pharmacol. Exp. Ther.,2000

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